Enclomiphene Therapy

Most treatment for low testosterone works by adding testosterone from outside the body — injections, gels, or pellets. Enclomiphene takes a different route: it prompts your body to make more of its own.

How it works

Your testosterone production runs on a signal loop between your brain and your testes. Enclomiphene blocks estrogen's feedback at the brain, which increases the hormones (LH and FSH) that tell the testes to produce testosterone. Because the signal comes from your own system rather than a syringe, the loop keeps working — which is why fertility is typically preserved and why stopping therapy doesn't leave your body without a way to make testosterone.

That is the opposite of how testosterone replacement works. Supplying testosterone from outside tells your brain to stop asking for it, which suppresses your own production and sperm output for as long as you stay on it — sometimes longer.

Who it's a good fit for

• Men with low testosterone whose testes still respond normally — the most common pattern
• Men who want to preserve fertility, now or in the future
• Men who would rather not inject, apply gel daily, or have pellets implanted
• Men who want a treatment they can stop without a difficult transition off testosterone

It is not the right choice for everyone. Low testosterone caused by testicular failure won't respond to a louder signal, and some men are better served by other treatment entirely. Bloodwork tells us which situation you're in before anything is prescribed.

What's included

Enclomiphene therapy at GreenTree is $200 per month, and that includes on-demand physician access through the patient portal — questions about dose, side effects, or how you're feeling get answered by your physician, not a call center.

Lab work is billed separately and is typically covered through your insurance. If you'd rather pay cash, our panel is $149.

Monitoring follows a set schedule:

• Baseline labs before starting, so we know exactly where you're beginning
• One month in — a full recheck to confirm the therapy is working and adjust if needed
• Every three months thereafter, for as long as you continue

An honest note on FDA status

Enclomiphene is not FDA-approved as a standalone medication. It is prescribed through a compounding pharmacy, which is legal and common in men's health, but it means the product hasn't been through the FDA approval process the way branded testosterone products have. Clinical research to date — including studies comparing it directly with testosterone therapy in men whose low testosterone stems from signaling rather than testicular failure — has been encouraging, and it continues to accumulate.

We tell patients this plainly, because the decision belongs to you and it should be made with the full picture. No treatment is promised to work for everyone, and results vary.

What to expect

Your first visit is an unhurried conversation about your symptoms — energy, sleep, mood, libido, strength, focus — and your history and goals. We order baseline labs, then review them together in plain language: what's actually low, what isn't, and whether enclomiphene is the right tool for your situation.

If it is, you'll know the cost, the monitoring schedule, and the honest trade-offs before you start. If it isn't, we'll tell you that too, and talk about what would actually help.